Gehaltsübersicht für Biology in Basel-Stadt

Tasks & Responsibilities:• Contribute to and/or lead early drug discovery projects within multidisciplinary teams up to clinical proof-of-concept studies in patients• Collaboratively design, execute, and interpret complex preclinical experimental studies for the validation and characterization of targets or therapeutic agents in the area of rare blood disorders bleeding/thrombotic disorders, hemoglobinopathies, etc…). May direct and oversee experimental design and results of associates and post-doctoral scientists.• Concurrently perform multiple studies, including working within a matrix research environment to coordinate with project leaders and other functions• Design experiments and analyze data using appropriate statistical methods and present data in a professional format suitable for external publication• Act as an experienced resource in project teams, and demonstrate clear and professional verbal and written communication• Maintains and builds a network of external expertise and is well connected to the drivers of new and emerging scientific innovation and technologies in this fast-progressing field.Must haves: • PhD degree (Post Docs are appreciated) in Life Sciences (cellular/ molecular biology, pharmacology, immunology or hematology) • 2 years of experience post-graduation with experience leading projects (industry experience is not required) • Experience in animal handling (surgery, injections etc, especially mice) • Significant scientific accomplishments and successful collaborations documented by publications in high-impact journals• Able to lead projects (will have to articulate during the interview what and how they led), be autonomous• Ability to present scientific data and concepts to colleagues and teams is essential, as well as presenting at external meetings.• Skillfully able to interact effectively with people, both internally and externally• You can communicate fluently in English• Excellent data management and record-keeping skills 

The perfect candidate is someone who has done a similar position in bioanalysis previously within a pharma (preferred) or a CRO or an experienced scientist with experience with small and/or large molecules very keen to learn and with a positive attitude. Please note the preference goes to the first profile (experience in pharma/CRO). In any case, the successful candidate will have an education within biology / biochemistry. On this position, the perfect candidate has strong experience on both small AND large molecules. This is a long-term contract with a potential internal opportunity afterwards.  Tasks & Responsibilities:Lead bioanalytical strategies to generate decision-enabling bioanalytical data with skilled data interpretation to meet and answer project needsResponsible for outsourcing activities in Bioanalytics (bioanalysis of non-clinical and clinical studies); resource and time planning, coordination and administrative management of studies with CROs.Manage the development, transfer and validation of specific and sensitive bioanalytical methods required for the development compound (drug), anti-drug antibodies (ADA), soluble targets and any concomitant/interaction compound in the given project.Manage and direct analysis of samples and timeline from preclinical and clinical studies for the project at CRO labs.Participate actively in PS subteams, act as primary contact person for DMPK project leader.Act as Bioanalytical Leader when required. Interact proactively with the assay development team.Ensure full compliance with the current global and local bioanalytical guidance and GxPs.Leadership in Bioanalysis: *remain current and continually develop expertise in bioanalytical science. Contribute to scientific consortia when required; *maintain current expertise in the validation and conduct of bioanalytical assays; *guide and manage the bioanalysis at CROs and ensure that most advanced and most efficient procedures are used.Provide technical leadership in issue resolution.Review protocols and other relevant documents and guide project teams in all aspects of bioanalytical work required for the project.Review and write reports for regulatory submissions; support filings and answer any questions about bioanalytics coming from the regulatory agencies.Maintain open links with other disciplines within the department and the organization.Advise Group Head concerning all needs relating to administrative processes, technologies and equipment. Inform him of all critical issues Must haves:Minimum 3 years in a similar position focused on bioanalysis in pharma or CRO (pharma preferred) OR scientist focused on bioanalysis Excellent work experience on both large and small molecules bioanalysis Strong vendor management experience, looking after outsourced studies to external CROsDegree in biology/biochemistry  

Scientific HPC and Cloud Computing Team Leader The University of Basel has an international reputation of outstanding achievements in research and teaching. It counts over 13'000 students and 4'300 researchers active in domains from humanities and social sciences to natural sciences, with a focus on life sciences and medicine. In this context, sciCORE serves as center of competence in scientific computing, maintaining advanced HPC infrastructure and petabyte-scale storage for active research and associated services (training, data management and scientific support). Our users actively engage with the latest advances in machine learning and AI, leveraging the power of GPUs, and extensively utilizing interactive computing methods. As part of the Swiss Institute of Bioinformatics and as one of the nodes of the national BioMedIT network, sciCORE offers a secure and private cloud-based research platform. We are looking for a Scientific HPC and Cloud Computing Team Leader, to commence on April 1, 2024 (or upon agreement) and join the senior management team at sciCORE, assuming responsibilities for the technological interests of the organization. If you like collaborating with talented people in a highly interdisciplinary academic work environment, we are eager to hear from you. Your position You will be responsible for overseeing the technical strategy, infrastructure development, and operational efficiency of our systems. You will collaborate with a team of talented IT professionals and researchers and work closely with key stakeholders, to align technology initiatives with research objectives and to foster innovation in scientific computing. In addition to managerial responsibilities you will participate in technical tasks related to sciCORE's IT infrastructure, including optimization and troubleshooting. Responsibilities Develop and execute a strategic technology roadmap supporting sciCORE's academic mission. Lead the design, implementation, and maintenance of IT infrastructure for high performance, scalability, and security. Manage a team of skilled technology professionals, fostering innovation and collaboration. Establish and maintain partnerships with technology vendors to to remain updated on IT trends. Oversee security governance and operations in coordination with the CISO. Coordinate budget planning and resource allocation with the senior management team at sciCORE. Manage open tenders for hardware procurement in coordination with the Facilities Controlling & Services Unit of the University of Basel. Your profile Essential A Master's degree in Information Technology, Computer Science, Engineering, or equivalent, with a strong background in scientific high-performance computing. Proven hands-on experience managing complex Linux-based HPC systems in a research or academic environment. Solid knowledge of infrastructure management using infrastructure-as-code frameworks. Deep technical knowledge of parallel computing architectures, cluster and cloud computing, storage systems, scientific software frameworks and cybersecurity. Demonstrated ability to translate complex technological concepts into strategic plans and practical solutions. Leadership skills with a track record of successfully managing cross-functional teams and fostering innovation. Experience in coordinating open tenders for hardware acquisition, including drafting technical specifications, evaluating bids, and managing vendor relationships. Ability to balance managerial responsibilities with a willingness to engage in hands-on technical work as needed. Fluent proficiency in spoken and written English and German. Desirable Experience in IT service management processes. Familiarity with a wide range of scientific domains, such as physics, chemistry or biology, and an understanding of the computational challenges in these areas. We offer you In this position you will work in a dynamic academic setup, driving impactful global research. You'll dive into cutting-edge HPC and cloud tech, shaping the University's scientific IT advancements for international competitiveness. We prioritize your growth, supporting your professional journey and networking through national and global events. You will benefit from the attractive social conditions of the University of Basel, which include a competitive salary by international standards. You will enjoy life in Basel, a city of quality living with culture, family-friendliness, high quality healthcare, and excellent public transportation system. Application / Contact Please submit your application including CV, letter of motivation and references through our online portal. For further information, please contact Dr. Lorenza Bordoli, Write an email The position will remain open until filled. Universität Basel4000 Basel

How does life emerge from molecules and cells? This is the central question that motivates us. With curiosity and passion, we investigate this question accros scale ranging from the atoms to multicellular organisms. The Biozentrum of the University of Basel is one of the world's leading life sciences institutes. With 32 groups and 500 employees, we are a dynamic and international research community that has spawned many fundamental discoveries in biology and medicine as well as several Nobel Laureates. Become part of our vibrant research community!In Prof. Torsten Schwede's group, we use computational methods to model protein structures, analyse protein-ligand interactions, explore the effects of mutations on protein structure and function, and classify protein families on a large-scale. We also explore artificial intelligence to characterise the dark proteome and pioneer automated methods for uncovering unknown protein functions.Within the SIB Swiss Institute of Bioinformatics, we develop SWISS-MODEL ( ), a widely used web-based platform for generating high-accuracy 3D models of protein structures and complexes for application in life sciences. We also develop the Protein Universe Atlas, a web resource designed to streamline the navigation through the extensive wealth of publicly available protein sequence and structure information.Your positionMicrobiotic proteins that are unique to the human gut can impact human health. The successful PhD candidate will develop a gut microbiome atlas to discover novel proteins and predict their macromolecular function and interactions using cutting-edge computational techniques. The research will involve an in-depth study of the evolutionary origin and biochemical pathways that underpin the unique role of these proteins in the human gut, using protein evolution and structural bioinformatics approaches. The generated hypotheses will guide subsequent experimental validation.The research is integral to the newly established Protein Universe Atlas project, involving active collaboration with computational and experimental groups, primarily with Dr. Tomasz Kosció?ek at Sano Centre for Computational Personalized Medicine in Kraków, Poland.Your profileMaster in molecular biology, bioinformatics, biochemistry, genetics or a related discipline.Strong interest or experience in microbiology, protein evolution, structural biology, and modern data analytics techniques.You can strengthen our team in at least one of the following areas: protein bioinformatics, metagenomics, data science.Good communication skills in English.Self-motivation, drive and ability to explore new research directions.We offer youThe successful applicant will conduct cutting-edge research using state-of-the-art infrastructure in the Biozentrum, which offers a highly diverse, interdisciplinary, collaborative and stimulating research environment. Salary and benefits are according to University of Basel standards.Basel is a cosmopolitan and multicultural city at the heart of Europe. Bordering three countries, Switzerland, Germany, and France, Basel provides a high standard of living with a thriving cultural atmosphere. The Basel area is Europe's most important Life Science hub with many small and medium-size biotech companies as well as global pharmaceutical players.4000 BaselPhD position in evolution and structural bioinformatics of human gut proteinsStart date is by mutual arrangement, with the possibility to start immediately

The Zampieri group offers a post-doctoral research opportunity in the context of systems pharmacology, computational biology and metabolic regulation. These positions will be based in the Department of Biomedicine ( ) in Basel, one of the world's leading locations for life sciences, home to several companies and institutions. The mission of the group is to understand fundamental mechanisms regulating short- and long-term metabolic adaptation to genetic and chemical perturbations to find new and unconventional therapeutic strategies, ranging from antibacterial to anticancer drugs. To this end, we develop new ways to combine state-of-the-art technologies in metabolomics with mathematical modeling.ProjectStudy how bacterial susceptibility to antibiotics depends on the metabolic and physiological states of bacteria. We are looking for a highly motivated Post-Doc researcher to study how bacterial susceptibility to antibiotics depends on the metabolic and physiological states of bacteria (60% wet lab and 40% computational).Your positionThe candidate will have the opportunity to exploit some of the cutting-edge experimental and computational methods, comprising constraint-based and kinetic modeling, statistical analysis of large datasets, high-throughput metabolomics, time-lapse microscopy, to investigate how to pharmacologically interfere with fundamental mechanisms in the regulation of bacterial metabolism. Available resources at the department include a mouse facility, high-end FACS, IT and microscopy facilities, the Life Sciences Training Facility (for gene expression and proteome profiling) and much more.Your main tasks will be:Apply and develop model-based and statistical approaches to analyze and interpret large compendia of metabolome profiling of small molecules effects on bacteria.Adapting existing and developing improved experimental protocols for the high-throughput metabolomics analysis of drug-perturbed bacteria across different growth conditions.Unravel the hidden potential of apparently inactive molecules in hampering bacterial infectionDetermining the underlying mechanisms that link antibacterial efficacy to the metabolic or physiological state of bacteria.Testing their relevance in host-like environmental conditionsSupport and preparation of scientific reports and journal articlesYour profileThe candidate is expected to have a strong background and interest in quantitative disciplines, excellent teamwork and communication skills in English. The candidate will have the opportunity to develop the following project with a lot of academic freedom and strong support from senior members in the lab, and at the same time to play an active role in shaping and in creating inspiring research and working environment. Essential:PhD in (Bio)Physics, (Bio)engineering, Biological Sciences, Microbiology, Biochemistry, Systems Biology, Molecular Biology, Bioinformatics/Computational Biology, or related fields.Experience in designing and running experiments with microbial cultures in the laboratoryExperience with programming language (e.g. Matlab, R or Python)Motivation to work in an international research environmentHighly desirable:Hands-on experience with key biochemical and molecular biological methodsExperience with and/or motivation to learn systems biology approaches, high-throughput methodologies.Good communication skillsInterest in mathematical modeling of metabolic and regulatory/signaling networkWe offer youIn line with our and Uni Basel values ( ), we are committed to sustain and promote an inclusive culture, ensure equal opportunities and value diversity and respect in our working and learning environment.You will have access to state-of-the-art research equipment in metabolomics, cell biology, time-lapse microscopy.You will work in a dynamic and highly interdisciplinary team including computer scientists, experimentalists and clinicians.You will be involved in cross-disciplinary collaborations and have training opportunities to further develop and grow your scientific interests.Access to a large consortium of experts in different disciplines, such chemistry, engineering, clinics, computational biology and (Micro- / Cell- / Immune-)Biology ( ).Opportunity to work in close contact with other basic- and clinical-research groups at the Department of Biomedicine and the Biozentrum in BaselSupport from highly competent, experienced team members and potential to lead projects with a high degree of academic freedom4000 BaselPost-Doc position in quantitative biology (Zampieri Lab)

How does life emerge from molecules and cells? This is the central question that motivates us. With curiosity and passion, we investigate the entire spectrum ranging from the atom to the organism. The Biozentrum of the University of Basel is one of the world's leading life sciences institutes. With 32 groups and 500 employees, we are a dynamic and international research community that has spawned many fundamental discoveries in biology and medicine as well as several Nobel Laureates. Become part of our community!We are looking to recruit a highly motivated PhD student for an SNF funded project led by Marc van Oostrum in the laboratory of Peter Scheiffele .Your positionIn an interdisciplinary project supported by an Ambizione grant of the Swiss National Science Foundation , we will investigate the molecular diversity of synaptic proteomes from in-vivo brain structures (see van Oostrum et. al., Cell 2023 ). Conceptually the research aims at understanding how synaptic proteins determine synapse-type specific connectivity and function. The project integrates molecular neurobiology with systems neuroscience and combines state-of-the-art mass spectrometry-based proteomics technologies with fluorescence activated sorting and in vivo labelling of defined synaptic populations within neuronal circuits. We are looking for a highly motivated student that is excited to learn and develop new technologies in order to drive biology.Your profileMSc or equivalent degree with a strong interest in interdisciplinary neurobiology across scales from molecules to circuits. The project involves mass spectrometry-based proteomics, stereotactic surgery, fluorescence-activated cell sorting, genome editing methods, and computational biology. Experience in any of these domains is benefical, but not required. More important are self-motivation, independence and analytical thinking of the applicant. The position is funded and salary is according to institutional guidelines.We offer youA project at the frontier of science to solve fundamental questions in neurobiology. You will have the unique opportunity to join a small team with close guidance by SNF Ambizione project grantee Marc van Oostrum while at the same time being embedded in an internationally leading group of dynamic and collaborative scientists, Phd students, postdocs and technicians. The Biozentrum provides a highly stimulating collaborative research environment with a fantastic infrastructure in a brand-new building, as well as state-of-the-art technology platforms for cutting-edge interdisciplinary research.Basel is an international city with people from 150 nations. Located on the border where three countries meet – Switzerland, Germany and France – it is Europe's most important life sciences hub. Basel provides a high standard of living and a rich cultural atmosphere.4000 BaselPhD student position in synapse-type specific proteome studies100%, funded; Start date is by mutual arrangement, with the possibility to start immediately

Postdoctoral Position in Natural Product Research (Pharmaceutical Biology) The Department of Pharmaceutical Sciences of the University of Basel is an Academic Drug Discovery & Development Center, which comprehensively covers academic drug research throughout pre-clinical and clinical research phases. The Pharmaceutical Biology Group (Head Prof. Robin Teufel) within the Department is searching for a postdoctoral researcher with training and experience in natural product research, biosynthesis, protein biochemistry and analytical chemistry. Your position A postdoctoral position is available in the research group of Prof. Robin Teufel that focuses on the isolation of bioactive natural products from microorganisms and plants as well as the elucidation of the underlying biosynthetic pathways. You will be exploring enzymes from plant natural product biosynthesis including their mechanistic and structural investigation as well as possible modification by bioengineering for the production of pharmaceutically useful natural products and lead compounds. The place of work is at the Pharmazentrum in Basel. Fluency in English (C2 level) is required. Your profile We are looking for a candidate with a doctoral degree in a field related to pharmaceutical biology, biochemistry or chemistry. Experience in natural product research is required. Knowledge in natural product analysis (especially mass spectrometry & molecular networking, NMR etc.), enzymology, protein design, structural biology, molecular biology, and/or bioinformatics is furthermore advantageous. As a postdoctoral researcher, you will also supervise master students on occasion. We offer you The candidate will join a dynamic multidisciplinary research group of pharmacists, chemists and biologists working on the isolation/characterization of natural products and the underlying biosynthesis in one of the world's hubs for pharmaceutical research. Enjoy the vibrant scientific community at the University of Basel with great possibilities for internal and external collaborations as well as state-of-the-art instrumentation and infrastructure both in-house and close-by. As part of our team, you will receive supportive mentoring, a generous salary and enjoy the high quality of life in Switzerland for two to a maximum of four years. Application / Contact We are looking forward to receiving your online application with the following documents: brief cover letter, up-to-date curriculum vitae (CV) and contact details of 2 referees. The CV should list relevant experience and/or academic coursework, which can confirm the candidate's training in the methods listed above. Please note that we exclusively accept applications submitted through our online application portal. Applications via email, postal services or agencies will not be considered. For general inquiries please send an email to Write an email https://pharma.unibas.ch/en/persons/robin-teufel/ Universität Basel4000 Basel

Laboratory Head in Neuromuscular DiseaseThe Position In Roche’s Pharmaceutical Research and Early Development organization (pRED ), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. The Position We are seeking a Laboratory Head to lead a Neuromuscular Research Group in the Neurotechnologies section within the Neuroscience and Rare Disease (NRD) therapeutic area. The primary focus of the section is on implementing and using novel delivery and RNA/DNA modifying techniques, as well as establishing suitable muscle disease models to develop therapeutics for some of the most challenging neuromuscular disorders. Our section works closely with other sections and groups within NRD as well as laboratories within our Therapeutic Modalities and Pharmaceutical Sciences groups and Data & Analytics to convert hypotheses into innovative therapeutics. Job mission We are offering an outstanding opportunity to lead a lab whose primary focus will be to establish in vitro models of muscle and neuromuscular diseases to better understand pathologies, test compounds, develop biomarkers, and suggest new therapeutic avenues. With a deep knowledge and experience in muscular and/or neuromuscular dystrophies, you will establish a new R&D working group in an exciting and fast-progressing therapeutic area. You will develop new therapeutic strategies and manage research programs in neuromuscular disorders. You will be responsible for applying scientific expertise and judgment to initiate, design, direct, and execute experiments and/or studies in support of research and/or development project goals in a time sensitive manner. You will have tremendous resources and capabilities, and you will be surrounded by world-class scientists and drug hunters in a state-of-the-art new building located at the pRED center in Basel. Your key responsibilities You are leading an effective team of Scientists and Associates to generate models of neuromuscular and muscular dystrophies. You are bringing deep scientific expertise about neuromuscular and/or muscular pathologies, respective disease models, and an overview on therapeutic approaches in the preclinical and clinical space. You possess hands-on experience in patient-derived cellular as well as physiological models. You implement cellular research models with endpoints that support understanding of patient disease and biomarkers. You are leading drug discovery projects and ensure successful translation of pre-clinical programs to a clinical setting. You have experience in preparing high quality documents including technical reports, presentations, SOPs, and experimental protocols. Experience in regulatory filings is a plus. You act as an impactful contributor and/or leader of project teams and seminal initiatives. You foster creativity, productivity, execution with a sense of urgency, teamwork, accountability, cross-functional collaboration, and employee growth and development. Who you are You completed a PhD or MD/PhD in science and bring a minimum of 8 yrs solid research experience (after your PhD) in the muscle biology or neuromuscular field. You bring a proven scientific-track record through impactful publications in the field of muscle biology or neuromuscular disease, patents, or substantial contributions to drug development programs. Experience in drug development is a clear asset for the role. You are a rigorous scientist with a strong expertise in cell-based and animal models of neuromuscular disease, including a solid grasp on the literature of disease mechanism and treatment avenues. You are someone who is driven by the desire to find therapeutics for some of the most devastating disorders. You possess excellent interpersonal and communication skills, enjoy teamwork, diligence and efficiency. You showed your capability to lead an independent research team. You are a kind and influential team leader and a trusted and knowledgeable colleague. You possess the flexibility to rapidly change priorities and deadlines and the ability to lead others through change in a dynamic, fast paced industry and work environment. Working in a multicultural environment motivates you. Our commitment Roche commits to recognising talent and aptitude. We prioritise encouraging and supporting our employees on their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career. We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be. Who we are At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity. Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more. Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events. We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche. Roche is an Equal Opportunity Employer.

Spatial Biology Matrix LeadThe Position In Roche’s Pharmaceutical Research and Early Development organization (pRED ), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. 360 Labs Initiative at a Glance The 360 Labs are a new capability that is currently being built up within the Pharmaceutical Research and Early Development organization (pRED ). The primary mission of this effort is to provide greater access and support for the use of cutting-edge biomedical research technologies by scientists across our discovery portfolio. Operating as an integrated ecosystem, the 360 Lab environment will deliver core scientific technologies, expertise and enabling activities, as well as facilitate knowledge sharing and learning experiences in close collaboration with our therapeutic areas and functions. Together, these efforts will serve to increase the speed, enhance the robustness and improve the sustainability of our exploratory research and early discovery activities. We are currently recruiting scientific professionals with varied backgrounds in Flow Cytometry, Genomics, Proteomics, Histopathology and Microscopy / Imaging. In these new roles, your collaborative mindset is as valued as your scientific expertise. The 360 Labs are by nature a hands-on, interactive workplace where face to face presence in our labs is a priority. Our ambition is to bring to life a thriving workplace environment, acting as an highly integrated ecosystem, supporting research and development, working collaboratively, and focused on fostering excellence and sustainability. Job Mission and Impact The 360 Labs Initiative is seeking a Matrix Leader for Spatial Biology. You will have a strong background in the development and application of spatial approaches (both genomics and imaging-based) to understand disease biology. You will operate as a part of a matrix team and will collaborate closely with the platform heads, lab scientists and data analysts from each of the 360 Labs technology platforms, as well as with experts from our therapeutic disease areas and functions to conceptualize and execute our spatial biology strategy to support discovery projects undertaken within the 360 Labs technology ecosystem. Your Role and Responsibilities Act as a strategic visionary, providing key guidance and oversight in the deployment and application of spatial biology approaches across the discovery research space in pRED. Serve as a key member of the 360 Labs leadership team, working closely with the Global Head, to develop a bold vision and strategy for spatial biology by close interaction with senior leaders and key stakeholders across pRED. Serve as a Matrix Leader collaborating across the 360 Labs technology ecosystem along with scientific experts from our therapeutic areas and functions to prioritize and implement innovative spatial biology strategies to enable the exploration of disease-relevant hypotheses. Work collaboratively to continually evolve our spatial biology strategy by innovating new approaches, staying up to date with the scientific literature, actively engaging with internal and external spatial biology communities, and continuously evaluating new technologies in the spatial biology space. Your Profile Required Proven track record of engagement with senior leaders and key stakeholders and leading cross-functional teams. A PhD degree in biology, chemistry, or a related field with 5 yrs professional experience in an academic setting and / or pharmaceutical industry / biotech sector. An experienced experimentalist with in-depth theoretical and hands-on knowledge in the development and application of genomics and imaging-based spatial biology assays to understand how cells organize and interact across complex tissue landscapes. Established track record of scientific accomplishments and successful collaborations documented via publications in high-impact scientific journals and presentations at international conferences. Familiarity with the bioinformatics tools and programming languages commonly used in the analyses and interpretation of spatial biology-related datasets. Strong awareness of the emerging trends and technology developments across the spatial biology space. In addition to your scientific expertise and critical technical skills we are looking for candidates who: are a strategic leader that can architect a compelling vision; serve as a coach to develop and mentor junior and senior team members; and act as a catalyst by leading by example; are curious, have a growth mindset, are resourceful and flexible in problem solving, have excellent organizational skills, can think outside the box, and have a demonstrated ability to implement new ideas in a fast-paced research environment; bring excellent written communication and presentations skills with a high fluency in English; have a keen interest in continuously building a personal network and who will thrive in a dynamic, inclusive environment which gives you full accountability for your own contributions and development; have an excellent understanding of the operations processes involved in early drug discovery & development. Your Location This position is based in Basel. Our commitment Roche commits to recognizing talent and aptitude. We prioritize encouraging and supporting our employees on their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career. We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be. Who we are At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we’ve become one of the world’s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity. Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more. Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events. We believe in the power of diversity and inclusion, and strive to identify and create opportunities that enable all people to bring their unique selves to Roche. Roche is an Equal Opportunity Employer.

Bioinformatician The Bioinformatics Core Facility at the University Basel is seeking a Ph.D. level bioinformatician. The facility is a centralized resource of expertise for the analysis and visualization of large-scale biological datasets, available to researchers at the Department of Biomedicine (DBM) and the Biozentrum (BZ).The position is initially limited to 3 years and it is available immediately or upon agreement. Your position Consultancy in the design of high-throughput experiments Computational analysis of -omics experiments, including expression studies (\"bulk\" and single-cell RNA-seq) and gene regulation studies (ChIP-seq, ATAC-seq, DNA variants calling), long reads sequencing, proteomics and spatial transcriptomics Set up robust and reproducible workflows to standardize analyses Integration of multi-omics datasets Teaching and training Help with data interpretation and contribution to manuscript writing Your profile Ph.D. in a quantitative field such as computational biology, statistics, physics, or mathematics with strong interest in biology Demonstrated experience in analyzing genomics or other high-throughput biological datasets Experience with analysis of proteomics or spatial transcriptomics experiments is a plus sound statistical knowledge and fluent programming skills using R/Bioconductor and/or Python are essential Excellent teamwork, collaboration and communication skills Proficiency in written and spoken English We offer you A stimulating, challenging and multifaceted research environment Good integration into the local and national bioinformatics community (the Bioinformatics Core Facility is part of the Swiss Institute of Bioinformatics). Possibilities for continued education and training Attractive employment conditions Workplace centrally located in Basel A good work-life balance and an equal opportunities environment. Application / Contact For informal inquiries please contact Dr. Robert Ivanek (Write an email). Please use only the link to submit your application with following requested documents: CV with highlighting relevant research experience, a cover letter explicitly detailing the reasons for our interest in the position, and contact details of two referees will be considered. Universität Basel4000 Basel